![]() ![]() Hence, the effect of cooked meat on serum creatinine might be higher in more advanced CKD stages. A study looking at the effect of protein load in renal transplant patients and healthy control subjects showed a 30% increase in serum creatinine, with the rise in absolute terms being higher in the transplant group ( 15). The maximum concentration of serum creatinine was achieved 2 h after the cooked meat meal. A large cooked meat meal (225 g) was shown to cause an average increase of 52% in creatinine compared with the mean value on a control meal in six healthy individuals ( 14). Ingestion of meals containing cooked meat caused a marked postprandial increase in serum creatinine concentration, whereas ingestion of raw meat had no effect on serum creatinine in normal human subjects ( 13). Studies looking at the effect of cooking on acid-extractable chemical constituents of beef have shown significant increase in creatinine levels ( 11, 12). Cooking meat converts creatine in skeletal muscle to creatinine. Habitual increase in protein intake leads to increased total muscle mass and the total body pool of creatinine, but acute ingestion of cooked meat causes a transient increase in serum and urinary creatinine. For women this level was 1.4 mg/dL and for men 1.5 mg/dL. Until now, the prescribing information for drugs containing metformin stated that people with moderately high levels of creatinine in their blood should not take it. GFR, renal plasma flow, and creatinine clearance have been shown to increase protein consumption and amino acid infusion, particularly in preclinical studies ( 8, 10). When you have impaired kidney function or kidney disease, your creatinine level will be too high. There have been several studies examining dietary protein and renal function ( 9). ![]()
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